Thursday, November 30, 2006

Statins - can lead to memory loss? - 06 December 2003

ONE day former astronaut Duane Graveline came back from a walk and failed to recognise his wife. He blamed this temporary bout of amnesia on the drug Lipitor, which he had been taking for several weeks. Doctors dismissed his fears, but six weeks after he started taking the drug again he suffered another bout of amnesia. This time he could not remember anything after high school, not even his children.

Graveline is one of a growing number of people who say they have suffered from amnesia and other nervous-system side effects after taking statins, the cholesterol-lowering drugs being prescribed to millions of people at risk of heart disease. And now a few researchers are starting to believe their claims.

Beatrice Golomb at the University of California, San Diego, who is studying the effects of statins on cognition and mood, says she has documented at least 100 cases of memory problems that might be due to statins, including 30 cases of transient amnesia. "It's probably fairly rare," she says. But with tens of millions of people taking the drugs worldwide, such problems could still affect thousands of patients. One of the reasons Golomb thinks statins are to blame is that in more than half the cases of amnesia, people suffered a second episode, a far higher relapse rate than normal.

Around 60 accounts of memory problems after taking statins were also found by a team from Duke University in North Carolina, who analysed the Medwatch database of drug side effects (Pharmacotherapy, vol 23, p 871). In some cases the patients' memory problems returned only when they resumed taking statins. This "re-challenge effect" is considered to at least hint at a causal relationship between a drug and a side effect.

Though statins are generally considered very safe, it would not be surprising if they affect neural function. The drugs block the synthesis of cholesterol, a key ingredient in cell membranes. Last year, a Danish study concluded that patients on statins have a substantially increased risk of polyneuropathy, a condition characterised by weakness and numbness in the extremities.

But many patients on statins are older and have a high risk of memory problems, P. Murali Doraiswamy of the Duke team points out. The key question is whether patients suffer a higher rate of memory problems than expected. Eight trials have shown no harmful or beneficial effect, he says. "No one should be discouraged from taking a statin because of such anecdotal reports. The benefits of statins far outweigh any possible risks."

Yet his team's paper concludes that "statins, in rare cases, may be associated with cognitive impairment, though causality is not certain". Golomb is convinced by the number of re-challenge effects she has seen that there is a causal link. But because these side effects are not recognised, doctors tell patients they're imagining things, she says.

From issue 2424 of New Scientist magazine, 06 December 2003, page 14

1 comment:

Anonymous said...

Perhaps you have seen the Direct-to-Consumer TV and print advertisements with Robert Jarvik, the inventor of the Jarvik Heart, speaking on behalf of the Pfizer’s anti-cholesterol drug, Lipitor.

Perhaps Jarvik is not the best choice for the Lipitor campaign which has had mixed reviews. Instead of Jarvik, a more convincing yet unlikely spokesman would be the popular Duane Graveline MD MPH, a former NASA astronaut, and author who was started on Lipitor during an annual astronaut physical at the Johnson Space Center, and 6 weeks later had an episode of transient global amnesia, a sudden form of total memory loss described in his book, Lipitor Thief of Memory.

Two more unlikely spokesmen for the Lipitor ad campaign include Mary Enig and Uffe Ravnskov.

Should either one be selected as Lipitor spokesman, I myself would run down to the corner drug store to buy up the drug. It seems unlikey that even Pfizer’s deep pockets could ever induce them to recant their opposing position on the cholesterol theory of heart disease.

Mary G. Enig writes, ”hypercholesterolemia is the health issue of the 21st century. It is actually an invented disease, a problem that emerged when health professionals learned how to measure cholesterol levels in the blood.

Uffe Ravnskov MD PhD is spokesman for Thincs, The International Network of Cholesterol Skeptics, and author of “The Cholesterol Myths, Exposing the Fallacy That Saturated Fat and Cholesterol Cause Heart Disease”. His controversial ideas have angered loyal cholesterol theory supporters in Finland who demonstrated by burning his book on live television.

For more discussion on this, see my newsletter: Lipitor and The Dracula of Modern Technology

Jeffrey Dach MD